The Science of Multi-Collagen: Explaining Types I, II, III, V, and X

The Science of Multi-Collagen: Explaining Types I, II, III, V, and X

The term "collagen" is often used interchangeably with skin health, but this essential protein is far more complex. It is the most abundant protein in the human body, serving as the primary building block for our skin, bones, tendons, and connective tissues. Crucially, collagen is not a single entity; it is a family of proteins, with at least 28 identified types. A high-quality multi-collagen supplement is designed to harness the benefits of several key types, specifically I, II, III, V, and X, to provide comprehensive, whole-body support.

At Skinnly, we recognize that maximizing the benefits of collagen requires a multi-faceted approach. Whether you choose our specialized Skinnly Marine Collagen, our dedicated Skinnly Beef Collagen, or our superior, full-spectrum Skinnly Multi-Collagen, understanding the roles of the different types is key to achieving your wellness goals.

Understanding the Major Collagen Types in Multi-Collagen

A true multi-collagen blend strategically includes sources rich in the five most prevalent and beneficial types of collagen. The distinct function and location of each type explain why a combined supplement offers superior results compared to a single-source product.

Type I Collagen

Type I is the most common form of collagen, accounting for over 90% of the collagen in the human body. Its structure is defined by dense fibers, giving strength and elasticity to tissues. It is found primarily in the skin, tendons, bone, teeth, and fibrous cartilage (Uitto, 1986). In supplementation, Type I is critical for:

• Improving skin hydration and elasticity.
• Supporting the structure and strength of **bones** and connective tissue.
• Promoting strong **hair and nails**.

Source: Bovine (Beef) and Marine (Fish).

Type II Collagen

Unlike Type I, Type II forms a much looser, more intricate network of fibers. It is the primary collagen component in **hyaline cartilage**, which is the tissue covering the ends of bones in joints (Bruckner & Van Der Rest, 2011). Because it is structurally and functionally different from Type I and III, its consumption is specifically targeted for:

• Providing cushioning and support for **joints**.
• Helping to maintain **cartilage health** and flexibility.

Source: Chicken Cartilage.

Type III Collagen

Type III is often found alongside Type I and is considered the second most abundant collagen in the body. It forms thin, branching fibers (reticular fibers) that provide a supportive scaffold in soft tissues. It is highly concentrated in the walls of blood vessels, muscles, organs, and the **intestines** (Barnes et al., 1974). Key benefits include:

• Supporting the health and integrity of the **gut lining**.
• Contributing to the structure of **blood vessels** and muscles.

Source: Bovine (Beef).

Type V Collagen

Type V is a minor but crucial component that helps regulate the formation of Type I and Type III collagen fibers. It is found in small amounts in skin tissue, hair, and the cells of the placenta. Functionally, it helps ensure the fibers of the more common types are assembled correctly, influencing tissue quality (Sun et al., 2018). Its inclusion is vital for:

• Optimizing the **quality and structure** of Type I and III fibers.
• Supporting the health and structure of **hair follicles**.

Source: Bovine (Beef) and Eggshell Membrane.

Type X Collagen

Type X is known as the "network-forming collagen." It plays a critical, temporary role in the **calcification of cartilage** during the process of endochondral ossification—the formation of bone from cartilage (Kirsch & von der Mark, 1990). Though its presence in the body is localized, its inclusion in supplements is prized for its contribution to:

• Supporting new **bone formation** and skeletal health.
• Aiding the process of **cartilage repair** and bone mineralization.

Source: Chicken and Eggshell Membrane.

The Skinnly Multi-Collagen Difference

The goal of a high-quality multi-collagen supplement is to transcend the benefits of a single source. By combining specific sources—typically bovine, marine, chicken, and eggshell membrane—Skinnly’s Multi-Collagen ensures the delivery of all five essential types: I, II, III, V, and X. This comprehensive approach ensures you are supporting the largest organ (skin), the foundation of your mobility (joints and bones), and the core of your health (gut integrity) simultaneously. Choosing a multi-collagen is choosing maximum efficiency for holistic wellness.

References

• Barnes, M. J., Bacchus, H., Bailey, A. J., & Marsden, A. (1974). Aortic collagen: evidence for the presence of a third molecular species in the rat. Biochemical and Biophysical Research Communications, 60(4), 1399-1405.
• Bruckner, P., & Van Der Rest, M. (2011). Structure and function of cartilage collagens. Journal of Bone and Mineral Metabolism, 29(1), 1-8.
• Kirsch, T., & von der Mark, K. (1990). Isolation of the major structural non-collagenous proteins from the chondrocyte growth plate. FEBS Letters, 266(1-2), 1-4.
• Sun, S., Sriranganathan, N., & Vepachedu, R. (2018). Collagen Type V: A Mini-Review. The FASEB Journal, 32(S1), 606.5.
• Uitto, J. (1986). Connective tissue biochemistry of the aging dermis. Clinical and therapeutic aspects. Dermatologic Clinics, 4(3), 433-441.